The goal of the study was to examine the relationship between psychological capital and psychological empowerment in the work environment among female workers at leadership positions in the public and private sectors. A questionnaire was distributed randomly between a sample of female workers with leadership tasks in the governmental and private sectors in the Jizan region. The research sample consists of (477) female workers with leadership position in the public and private sectors, including (312) female workers in the government sector, and (165) in the private sector. The data were analyzed using SPSS by multiple regression analysis, Pearson’s correlation coefficient, t-test for significance of differences, and analysis of variance. The results indicated that there is a positive, statistically significant relationship between the sources of psychological capital and psychological empowerment in the work environment among the female workers with leadership tasks in the public and private sectors. The implications, and recommendations also discussed.