The objectives of the study were to determine the satisfaction of pharmacists in five practice areas with various elements of their work environment and to evaluate the relationship between demographic parameters like age, gender, and academic degree and the satisfaction of pharmacists with their working environment. The study was a cross-sectional survey of pharmacists in Nigeria. The population of the study included graduate pharmacists and the sample size was determined to be 618 (attrition considered). A simple random sampling method was employed, and a set of pretested questionnaires was used to collect data for the study. The results showed that most of the respondents in the different areas of practice were not satisfied with their working environment especially hospital pharmacists (χ2 (4) = 9.652, p = .047). Most of the respondents who were younger in age (χ2 (3) = 17.346, p = .001), not married (χ2 (3) = 12.558, p = .006), with few years of experience (χ2 (5) = 47.701, p = .000, who belong in the lower cadre (χ2 (2) = 32.641, p = .000) and were first degree holders (χ2 (2) = 9.228, p = .010) were not satisfied with their work environment. The study revealed that pharmacists in Nigeria are not satisfied with their work environment. However, the satisfaction with the work environment varied with age, marital status, cadre, years of experience, level of education, and across practice settings, with the pharmacists in academia being the most satisfied and the least satisfied hospital pharmacists.
