Nowadays, social exclusion approach is a critical and applied perspective for studying the status of people in the society. This multi-dimensional approach to the study of deprivation makes it possible to identify all the aspects of this phenomenon. This study examined the reliability and validity of social exclusion measurement tool in female-headed households. After translating, editing and appropriating the Hoff and Vrooman’s questionnaire (2012), face validity and content validity were conducted.Test-retest of the questionnaire was carried out to measure the reliability. Construct validity was conducted through known-groups method; and both exploratory and confirmatory factor analyses were performed.The results of content validity ratio (CVR) revealed that all questions were equal to or higher than 0.78 and none of the questions was found to be less than 0.79 in the content validity index (CVI) results. The Impact score of all questions was more than 1.5. Cronbach’s alpha was 0.887. test – retest shows that the questionnaire has high and significant correlation. ICC was equal to 0.942. the results of known group’s method show that the questionnaire was well able to separate the two groups. The results of factor analyses (exploratory and confirmatory) show that the exploratory model has an acceptable fitting.