It is important to pay attention to Isfahan City as the main center of Isfahan school in architecture and urbanism to protect and model urban elements. So, to provide appropriate guidelines on how to intervene in historical places, it is adequate to investigate and consider them at various scales, from local to urban. In most studies on Isfahan City, neighborhood centers, as one of the significant functional spaces, have been usually neglected. These elements, which are functionally one of the smallest urban spaces and typically provide services in neighborhoods, have faced severe threats due to changes in the structure of Iranian urbanism, including widening of streets, physical changes, etc., after the arrival of modernism in Iran and no serious attempts have been made to maintain them. Therefore, the present study aims to document them and explain their spatial, physical, social, economic, and environmental characteristics to help today's designs on the local scale. Moreover, it is attempted to typology neighborhood centers, especially morphologically, to examine various forces playing a role in their formation. Research findings indicate religion, economy, and climate have tangibly influenced the formation of these neighborhood centers. Moreover, it can be said that the typology aims to explain the indicators affecting the physical typology on the middle scale and also to identify the primary type of neighborhood centers in Isfahan according to land use, enclosure, access, and geometry indicators. The samples are also selected using field studies and the typo-morphology technique.