The present study was conducted to examine the relationship between social and family support and hardiness with attitude towards infertility in infertile women in Mashhad. The population was all infertile women in Mashhad who were sampled voluntarily. The infertile women willing to answer the questions of the questionnaire were invited, and 49 people referring to perform in vitro fertilization (IVF) in Novin Infertility Clinic, Mashhad, or referring to Najafi Health Center, Mashhad for post-operative care during pregnancy were selected as the sample and responded to Social and Family Support, Kobasa's Hardiness, and Attitude towards Infertility questionnaires. Descriptive statistics (mean and variance) and inferential statistics (Pearson correlation coefficient and Spearman) were used for data analysis. SPSS software was used reach the results faster. The results showed no significant correlation between social support and attitude towards infertility. Moreover, there was a significant negative correlation between the components of commitment, challenge, control (components of hardiness) and attitude towards infertility.