The purpose of this study was to explain the mediating role of Self-esteem in the relationship between personality traits and mental health among female managers in region 1 of Shiraz. A correlation-descriptive method was used for this study and the statistical population included 234 female managers in a Shiraz city; in order to select the sample group, 140 people were selected by simple random sampling method and Morgan table. Three questionnaires including personality traits, mental health and self-esteem questionnaires were used to collect data from the population. Data were evaluated in order to extract and analyze the data at descriptive and inferential levels. Mean, standard deviation and research variables were evaluated at the descriptive level; and the hypothesized model was tested at the inferential level using the path analysis method by Baron and Kenny. The results showed that self-esteem has a mediating role in the relationship between personality traits and mental health among female managers in region 1of Shiraz. Personality traits can predict self-esteem; Self-esteem can predict mental health; Personality traits can predict mental health.
