The aim of this study was to investigate the effectiveness of Habit Reversal Training on Anxiety, Quality of life and Symptoms of Trichotillomania patients. This quasi-experimental study was examined with the pretest-posttest design. The population consisted of all female patients with Trichotillomania disorder referring to the Mashhad medical clinics. A sample of 24 persons had criteria for entering the research, were randomly selected and randomly divided into two experimental (12) and control (12) groups. The experimental group was trained in Habit Reversal for 8 one-hour sessions, while the control group did not receive such training. Data were analyzed by ANCOVA & MANCOVA test using SPSS18. The results showed that Habit Reversal Training had a positive effect on quality of life, anxiety, and Symptoms of Trichotillomania patients so that the experimental group showed less anxiety and Symptoms of Trichotillomania after the intervention and a higher quality of life. According to the results of this study, it can be concluded that Habit Reversal Training has a positive effect on anxiety, quality of life and Symptoms of Trichotillomania of patients with Trichotillomania. Therefore, Habit Reversal Training should be considered as one of the main treatments for the disorder.