Empowerment of human resources is considered one of the main attitudes of contemporary management in improving job performance. Thus, the psychological empowerment of nurses to modify their job performance has been given specific attention by the senior managers of the health system, because the improvement of the job performance of nurses causes better treatment of patients, improvement of the medical services quality, and generally improves the general health of the society. The present research method is descriptive-correlation according to the regression analysis. The statistical population of this research was 366 people, of which 188 people were selected by stratified random sampling. The data of the research was collected using three standard questionnaires and was carried out by the statistical methods of correlation test and hierarchical regression analysis through SPSS23 software. Based on the results of this study, the psychological empowerment of nurses has a positive and significant relationship with their job performance. Also, each dimension of nursing managers' communication behaviors has a moderating role in the relationship between nurses' job performance and psychological empowerment (P<0.05). It is suggested that nursing managers take actions such as: giving nurses delegation of authority and freedom of action, trying to reform the payment system, holding psychological training courses, maintaining and managing health psychiatric nurses, holding periodical meetings, and involving nurses in exchanging opinions on disputed issues, and supporting and encouraging nurses in organizations, increase their ability and job performance.