The teaching of CDIO-oriented courses in the form of project-based learning is a new direction to meet the social demand for high-quality human resources. The article aims to test the impact of the following factors: Learning motivation, Consistency in learning; Competition in learning; Learning methods; The university brand on the learning results of project subjects oriented to CDIO of Vinh University students. Quantitative research methods were used in this article with survey data of 200 students of diverse majors at Vinh University through analysis of linear structural model SEM. Research results show that 4 factors are affecting academic results in learning project subjects oriented CDIO of students at Vinh University, including 3 original factors: Learning Method, Consistency in learning, and University Brand and a new factor "will to learn" has a positive correlation with learning results. On that basis, some recommendations are made to affect the factors of the model, to improve the results in learning project subjects of Vinh University students, meeting all 4 pillars of the CDIO.