Today, an attitude toward knowledge has changed throughout the world, because the knowledge is the driving force of the countries’ economy. Creating the strategic competitive advantage requires a new type of organizations which have the potential to create knowledge in order to maximize the competition and strategic success. Knowledge, like other important resources of the survival and success of an organization in the global market, is vital and decisive. Knowledge management is an important tool through which organizations can better manage the knowledge and information. Creating, storing and applying knowledge is one of the duties of knowledge management. This research studied the readiness of one university in Iran for establishing the knowledge management. The statistical population are professors and employees of Islamic Azad University, Science and Research Branch. Various effective factors for accepting knowledge management were considered in this study. The results of the study showed that the conditions of different factors for establishing knowledge management in this university are nor suitable.