Today, among the various management practices, total quality management (TQM) is a way to achieve significant results and achievements in the field. Therefore, this model plays an important role in solving complex organizational problems in today’s turbulent era. Therefore, the present study examines the effect of TQM and its dimensions on business performance of Ahvaz manufacturing companies. This research is descriptive-causal in terms of type and nature, and applied research in terms of purpose. The statistical population of this research is all active manufacturing companies in industrial towns of Ahvaz, which was selected through Cochran formula of 217 companies and the questionnaire was distributed by simple random sampling method. In this research, we used questionnaires prepared by Moghimi (2011) for TQM variable and Santos-Wijandi (2012) for business performance variable. In this study, SPSS and LISREL were used to analyze the data. Findings of the research indicate that TQM and its dimensions have a positive and significant effect on business performance.