Since the World Health Organization announced the Corona Pandemic in March 2020, the world has faced many challenges and fundamental lifestyle changes. This study aims to identify lifestyle changes such as diet, marketing habits, daily activities, and sleep patterns in the western region of Saudi Arabia (SA) during the COVID-19 quarantine period. Besides, this work aims to investigate the relationship between lifestyle changes and weight changes. A retrospective cross-sectional study conducted in the western region, SA during the COVID -19 quarantine between May 2020 and January 2021. The descriptive research approach was adopted using a questionnaire. Subjects who met the admission requirements and completed the questionnaire was 539. The majority of participants’ ages 35-44 years, they were mainly women (73.3%). The percentage of those who work from home (online) was 31.2%. Most respondents rely on home-cooked food during the quarantine period (84 %), and the proportion of people eating out at restaurants is declining. About half of the participants reported emotional eating (54 %), and the majority preferred sweets. 42.4% of participants did not store additional food or worry about food insecurity. 44 % of participants revealed weight gain. There were strong correlation between increased weight in the study participants and emotional eating (p < 0.001), physical exercise (p < 0.001), and the number of fast-food consumed per week (p< 0.05). This work showed that weight gain in people during the lockout period could be attributed to the reduction in exercise and physical activity and the increased in emotional eating.
