Purpose of the study: The main objective of present study was to evaluate the information-seeking behavior of postgraduate students of Kerman University of Medical Sciences and to find their information-seeking weaknesses and strengths based on the principles of least effort and cost-benefit. Methodology: This research was a survey type of study. The data collection tool included a researcher-made questionnaire. The research population included postgraduate students of Kerman University of Medical Sciences. The sample of the research included 168 people. In analyzing the data, mean, standard deviation, t-test, Kolmogorov-Smirnov test, two-sample T mean and regression analysis in SPSS16 software were used. Results: The research revealed that gender had no effect in the quality and accessibility of information-seeking behavior based on the principle of the least effort and the principle of cost-benefit. In addition, the research results indicated that the field of study was an effective factor in the quality of information in students' information-seeking behavior, for example, students of Faculty of Management, more than other students, were seeking for quality of information and they gave more value for it. It might be due the fact that they have higher knowledge of databases and information-seeking skills due to the nature of their field of study. In addition, the field of study was not found to be an effective factor in information accessibility, as no difference was found among different faculties in terms of the accessibility of information. Conclusion: The research results could be effective in improving the information-seeking behavior of students. The conditions can be provided for presenting better and high-quality scientific products by identifying the current problems in accessing high-quality information.