Given the competitive market environment in recent years, entrepreneurial orientation (EO) and knowledge management (KM) have received more attention as components of improving organizational performance. This research examines the impact of EO and KM on the organizational performance of Razi Insurance Company. This is an applied research study in terms of purpose, quantitative in nature, and descriptive-correlational in terms of the data collection method. The statistical population consists of all managers and employees in Razi Insurance Company, of which 97 answered the questionnaire. The required data were collected using a questionnaire extracted from the studies of Lumpkin and Dess (1996), Gold et al. (2001), Murphy et al. (1996), and Parnell et al. (2006). Structural equation modeling (SEM) was employed in Smart PLS software to fulfill the research objectives and test the research model. The validity and reliability of the research tool were obtained by estimating the measurement model and applying the necessary corrections. The research results indicated a significant direct effect of EO and KM on organizational performance. It was also found that EO has a significant direct effect on KM, while EO indirectly affects organizational performance through KM. In other words, it was demonstrated that KM plays a mediating role between EO and organizational performance.