The purpose of this study was to compare the SMN method and low-calorie diet (LCD) to lose weight and enhance the self-esteem of people with overweight. In this clinical trial, and the population consisted of all overweight individuals referring to the nutrition clinics in Ardabil, the northwest of Iran. For this aim, 30 healthy women (BMI >25 kg/m2, age: 18-30 years) were randomly selected (for each group: 15 subjects). The Anthropometric measurement was done and the Eysenck Self-esteem questionnaire was completed before and after intervention among these persons. In this study, repeated measures ANOVA was used for analysis. The findings showed that there was a significant difference between two groups of SMN method and LCD (P<0.05). Also, the effect of SMN intervention on Lose weight and enhance the self-esteem of people with overweight was more effective than the effect of LCD. (Method SMN (self-esteem: 1.42±.10, weight:72.26±10.70kg) and method LCD (self-esteem: 1.89±.07, weight: 73.26±8.62kg)).