The purpose of this study was to compare the effects of Lean and Agile strategies on improving the performance of food and beverage companies in Shiraz. The present study was conducted on the basis of descriptive-survey design and it is an applied research, in term of purpose. The sampling was done randomly. The statistical population of the study consisted of managers and experts of the food and beverage companies in Shiraz. The required data for assessing and measuring were collected by questionnaires and in the form of fieldwork. In this regard, 178 questionnaires were collected. Data were analyzed using the structural equation modeling in LISLER software. In the present study, structural equations were used to test the first and second hypotheses to determine the magnitude and severity of lean and agile supply chain strategies on improving the performance of manufacturing companies, and t-test was used to test the third hypothesis to compare the effect of lean and agile supply chain strategies on improving the performance of manufacturing companies. After analyzing the hypotheses, it was concluded that the application and implementation of lean and agile supply chain strategies impacts the performance improvement of manufacturing companies, and there is a significant difference in terms of the superiority between the implementation of each of these two strategies. Finally, the output of the research shows that all hypotheses were confirmed.