Introduction: Professional ethics has turned into a special issue for many years. Physicians, nurses, medical staff, etc. are the most important individuals that their adherence to professional ethics not only increases their occupational health but it can also be considered as a therapy infrastructure. Methods: This is a descriptive cross-sectional study. The population included 100 cancer patients of Emam Reza and Taleqani hospitals of Kermanshah. The level of trust of patients in physicians and the medical staff was assessed with the Wake-Forest questionnaire. This questionnaire was evaluated by 3 faculty members of Tehran and Ilam medical sciences universities and content validity was analyzed. Results: The trust level of patients in physicians is more than their trust level in medical staff. The questionnaire had high reliability. The mean score of patients’ trust in physicians was 26.74 percent, while the mean score of patients’ trust in the medical staff was 22.52 percent. The data obtained from the questionnaire had a normal data distribution. A significant relationship was witnessed between some of the demographic variables and the score obtained from the questionnaire. Conclusion: The Wake-Forest questionnaire has high reliability to test trust level s in physicians and medical staff. The higher trust level meant more referring of cancer patients to the physicians. Thus, this questionnaire can be a highly important instrument in the evaluation of the professional ethics of physicians on specific patients.