The urgency of the problem is due to the importance of identifying psychological factors and conditions that determine the existence of various types of people's attitudes to dangers. The study aimed to identify the interrelationships of neuropsychological systems of activation and inhibition of behavior with personal factors and people's attitude to dangers on the example of students. The study involved 327 students from four universities of the Russian Federation (Moscow, Cherepovets, and Ivanovo). Among them, there were 60 men and 267 women. The average age is 20 years old (SD =2.17). As the diagnostic tools the author's questionnaires to identify sensitivity to threats and the choice of ways to respond in situations of danger, the Carver-White questionnaire to identify sensitivity to BAS/BIS (Behavioral Activation System/Behavioral Inhibition System), the questionnaire for the diagnosis of five personality factors (the “Big Five”) in the adaptation of L. F. Burlachuk and D. K. Korolev, the questionnaire “Adaptability” Maklakov-Chermyanin (scale “Moral normativity”) were used. Mathematical processing was carried out using correlation analysis methods. As a result, it was found that an adequate response to dangers is associated with personal qualities (openness to experience, benevolence, normativity of behavior), and exaggeration and understatement of dangers - with neuropsychological properties (BIS and BAS). The results can be used in the process of organizing work to ensure safety in various spheres of human activity, as well as in the educational process in the course of teaching the younger generation and adults adequate ways to respond to hazards.