The presence of a disability in one of the family's children not only affects the parents but can also cause various problems for all family members. Family life, when one of the children has a disability, often revolves around the needs of that child. For this reason, parents have less time to spend with other children, and this makes those children think; they are not as important to parents as children with disabilities, and this issue in turn leads to feelings of unhappiness and behavioral problems in them. Therefore, the current research was conducted with the purpose of the study of the mental health of children with siblings with physical and mental disabilities. The current research is retrospective descriptive research. The statistical population includes all normal students and students with a sibling who has physical and mental disabilities registered in schools and multi-disability rehabilitation centers. The number of 160 students (80 children with disabled siblings and 80 normal people) was selected as a statistical sample by cluster method. Self-esteem questionnaires (Cooper-Smith) and the new anxiety test (Reynolds and Richmond) were used independently to analyze T data to evaluate mental health. Statistical tests of analysis of variance were used. The results of the tests used showed that children and teenagers who had a disabled sibling had a high level of anxiety compared to normal peers, but the difference was not significant in terms of self-esteem.