Human rights violation is one of the most important socio-political issues, which happens by different groups with various beliefs. One the most important types of this violation related to the misperception of religion. The greatest and the most heinous violation of human rights may exist in war. Nowadays various religious groups declare war in the name of religion in order to make peace for people but these kind of actions spoil people tranquility. These groups assign their actions to religion. They claim that religion and its teachings encourage them to perform these actions. For instance, ISIS has the most violent behavior at war. They believe that they have done these actions based on Islam and Quran. Therefore, this study seeks to analyze the issue of Jihad and war in Islam based on Quran verses and intents to look into whether Islam and Quran encourage Takfiri groups to do the violent actions or there are other factors involved. At first, we express the definition of Jihad and its variants and we will explain it in details that variants of Jihad have a holy purpose. It will be stated that development of Jihad has certain rules while certainly these kinds of Jihad have not known as the part of Islam. Quran prohibits such violent behaviors and actions. One of the most important aims of this study is to express prisoners’ rights in a war and how to treat them. Because nowadays it is obvious that the most violent treatments to prisoners related to ISIS. Finally, this research expresses the positive and ideal results of Jihad on the context of human rights.