This study aims to investigate the relationship between technological acceptance factors (perceived usefulness, perceived ease of use, trust, and habit) and technological readiness factors (optimism, innovation, resilience, and anxiety) regarding the intention to use mobile applications in tourism (TMAs) among Generation Z in Vietnam. With empirical data gathered from 532 Gen Z respondents using structured questionnaires, the suggested research model was estimated using partial least squares structural equation modeling (PLS-SEM). The findings show that technical preparedness indirectly impacts the desire to use TMAs through the mediating effect of technology acceptability rather than having a direct impact. Perceived utility, perceived ease of use, and habit are favorable characteristics in technological acceptance; however, trust does not have a substantial influence. In order to improve digital tourism applications, make them more useful and simple to use, harmonize and integrate multiple features into one TMA application, and make it easily accessible to Gen Z, this study offers practical implications for tourism authorities, mobile application developers, and tourism businesses. Additionally, unique and distinctive product packages are needed to provide Gen Z with more digital tourism experiences.