The study aimed to evaluate the direct and indirect effects of employees’ trust and opportunistic behavior on business performance through intermediaries, engagement, and knowledge sharing. Using quantitative research methods through analysis of linear structure model SEM, the study surveyed 884 samples at companies in Vietnam. The findings showed that trust and opportunistic behavior affect the business performance of companies through intermediaries directly and indirectly. In particular, trust has a positive effect, while opportunistic behavior has a negative effect. In addition, the study also showed a positive impact of employee engagement on knowledge sharing. Based on these results, it is essential to encourage the sharing of information between employees and managers as well as to improve knowledge-sharing activities inside and outside enterprise. Enterprises should strengthen activities that supervise the working processes of all employees in the organization. Businesses should focus on building a harmonious working environment and promoting the spirit of solidarity among individuals, colleagues and managers.