Nihilism knows it impossible to gain insight of the world and believes that any sort of belief and faith related to the universe-related issues is void. It also holds that the human beings and the world have not been created purposively. Decline in the religious mindset is one of the factors having caused the meaninglessness of the life of today’s human beings. Essentially, the religious conception is the faith in the idea that there is a plan and objective in the word and that the world is an ethical system featuring a special goal and program. The human life, as well, is based on a goal and meaning; and, the movement and conduct of every individual is based on his or her goals and ideals and it can be perhaps stated that the purposiveness of the human life equals its meaningfulness. The followings are the goals the present study is looking for: investigation and criticism of nihilism philosophy and trying to find solutions for fighting nihilism. The new approach of the present study is criticism of philosophical nihilism based on an Islamic perspective. Moreover, there is made an ontological investigation of nihilism to offer solutions for invalidating and fighting nihilism.