Patient care is the most sought after concern of the healthcare sector. In order to deliver an effective patient care, the role of paramedic staff particularly nursing staff cannot be overlooked. This paper underlines workplace distress facing nursing staff in the major government and private hospitals in Pakistan. Lack of motivation, reward, work satisfaction and workload are some of the factors identified to cause increased turnover among nurses in the previous literature. The current paper’s aims are twofold; firstly, it examines various organizational and personal factors that influence job satisfaction of registered nurses and secondly, it investigates the mediating role of burnout in the relationship between organizational/personal factors and job satisfaction. It is hypothesized that organizational resources (staffing adequacy) and personal resources (psychological capital) significantly affect job satisfaction of the nursing staff and that burnout (emotional exhaustion and cynicism) mediates the relationship between organizational/personal resources and job satisfaction. The sample comprised of 270 registered nurses working in major public and private hospitals of Lahore, Pakistan. The data were collected through survey technique and standardized questionnaires were distributed using convenience sampling technique. Data were analyzed using Pearson Correlation, mediated regression analysis, Sobel’s test and bootstrapping. Study results revealed a moderate and significant correlation among organizational resources, personal resources and job satisfaction. Mediated regression analysis and bootstrapping technique revealed full mediation among staffing adequacy and job satisfaction (Bias-corrected CI [.0220 to .0900]). Lastly, burnout partially mediated the relationship among psychological capital and job satisfaction (Bias-corrected CI [.0077 to .0661]). Both organizational and personal workplace factors are important to registered nurses’ burnout and job satisfaction. The findings of the study have various managerial implications that hospital management may refer to for better management of its human resource and in taking more informed decisions.