Employee negligence (EN) in organization plans and not performing the tasks in a timely manner by the employees and management are alarms of reduction in organizational performance. The present study was conducted under the title of “Identification and ranking the factors affecting EN (Case study: Social Security Organization of Isfahan).” The study was applied regarding the purpose and descriptive-survey in terms of the nature and data collection method. Cochran formula was used to determine the sample size, according to which the sample size was 205 people. In addition, random convenience sampling method was used to collect data. The existing literature and interview with 14 managers, who were sampled purposively, were used to extract the items of the questionnaire. Cronbach alpha was used to determine the reliability of the questionnaire. Cronbach alpha for all the factors playing a role in negligence was above 0.7. SPSS22 was used for data analysis and PLS2 software was used for fitting the model. The results of testing the hypotheses showed that occupational stress, knowledge management, human resources training, job satisfaction and organizational silence all have a positive and significant role in EN of the Social Security Organization (SSO).