The article aims to evaluate the factors affecting the business performance of enterprises. The questionnaire was sent to accountants, chief accountants, departmental managers, directors, and CEO of 283 Vietnamese enterprises, of which 255 responses were valid. Suggested factors included financial resources, management, business, marketing, technology capacity, and working premises. The research methods used included descriptive statistical analysis, reliability assessment, exploratory factor analysis, and linear regression analysis from SPSS 20 software. The research results show that the financial factor has the greatest and most positive influence on business performance (the highest regression coefficient is 0.406), followed by the factors of management, marketing, and business capacity. business and technology have a positive and significant effect with regression coefficients from 0.112 to 0.117). There is insufficient evidence to assess the impact of working premises on the business performance of Vietnamese enterprises. The research results suggest implications for the Vietnamese Government in supporting business enterprises and Vietnamese enterprise managers in improving business performance.