Introduction: Systemic inflammation plays an important role in the development of atherosclerosis. IL1β and TNF-α are the most important inflammatory markers in the pathogenesis of atherosclerosis that the effect of physical activity and herbal medicine on its response is not well known. Method: Experimental study was performed and 36 adult male Wistar rats were randomly divided into six groups, including control, practice, linen dose of 10 mg / kg, linen dose of 20 mg / kg, flax training dose of 10 mg / kg, kg20 divided. The training groups performed aerobic exercises for rodents at a specific hour during the day for 8 weeks and five weeks each week. Fat oil groups consumed flaxen every day for 8 weeks. After the end of the period, blood samples were taken from rats and used for the measurement of IL1β and TNF-α. For analysis of data, Kolmogorov Smirnov test, one way analysis of variance and LSD post hoc test were used. All data was analyzed using SPSS17 software (α ≥ 0.05). Results: IL1β and TNF-α decreased in all groups compared to control group (α ≥ 0.05). Conclusion: In general, the results of this study showed that the combination of training and flaxseed oil reduced IL1β and TNF-α compared to the control group. Therefore, it is likely that this method can be used as a way to prevent cardiovascular disease and other inflammatory diseases.
